Framed for crimes against the country, the G.I. Joe team is terminated by Presidential order. This forces the G.I. Joes into not only fighting their mortal enemy Cobra; they are forced to contend with threats from within the government that jeopardize their very existence.

From the Egyptian desert to deep below the polar ice caps, the elite G.I. JOE team uses the latest in next-generation spy and military equipment to fight the corrupt arms dealer Destro and the growing threat of the mysterious Cobra organization to prevent them from plunging the world into chaos.

G.I. Joe faces a new enemy as an ancient society of snake people known as Cobra-La try to forcefully take back the earth from those who drove them underground eons ago.

Joe, a young American soldier, is hit by a mortar shell on the last day of World War I. He lies in a hospital bed in a fate worse than death – a quadruple amputee who has lost his arms, legs, eyes, ears, mouth and nose. Unbeknown to his doctors, he remains conscious and able to think, thereby reliving his life through strange dreams and memories and unable to distinguish whether he is awake or dreaming. He remains frustrated by his situation, until one day when Joe discovers a unique way to communicate with his caregivers.